Scientists have made a significant breakthrough in spinal cord injury treatment, discovering that electrical stimulation of a specific brain region can help patients regain the ability to walk. The study, published in Nature Medicine, highlights the potential of brain stimulation in enhancing mobility for those with incomplete spinal cord injuries.
Researchers in Switzerland, known for their pioneering work in electrical stimulation therapies, focused on the lateral hypothalamus—a brain region associated with arousal, feeding, and motivation. By using deep brain stimulation, the team was able to amplify signals from this area, improving communication between the brain and the spinal cord.
\"Now when I see a staircase with just a few steps, I know I can handle it on my own,\" shared Wolfgang Jaeger, one of the trial participants. Jaeger, along with another patient, reported significant improvements in mobility and confidence after the procedure.
The study involved implanting electrodes in the lateral hypothalamus, connected to a device in the chest that sends electrical pulses to the brain. Initial tests on rats and mice showed immediate improvements in walking, leading to human trials. The first human participant expressed, \"I feel my legs,\" when the device was activated, and both patients were able to achieve their mobility goals, including climbing stairs independently.
While the results are promising, further research is needed to determine the technique's effectiveness for a broader range of patients. Neuroscientist Gregoire Courtine emphasized that the success depends on the residual signals in the spinal cord and acknowledged that some patients may be hesitant to undergo brain surgery. The research team suggests that future treatments may involve stimulating both the spinal cord and lateral hypothalamus to maximize recovery.
This innovative approach offers hope for spinal cord injury patients, providing them with enhanced mobility and independence. As the technology advances, it may pave the way for new therapies that leverage the brain's potential to overcome physical limitations.
Reference(s):
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